Table 1.
Median survival, tumor spectrum and LOH in mice with indicated genotypes.
| Tumor types | Irradiated | |||||
|---|---|---|---|---|---|---|
| −/+;ErbB2 (n = 19) | H/+;ErbB2 (n = 22) | +/+;ErbB2 (n = 9) | −/+;ErbB2 (n = 16) | H/+;ErbB2 (n = 17) | +/+;ErbB2 (n = 16) | |
| Mammary | 86% | 95% | 100% | 75% | 59% | 88% |
| Lymphoma | 10% | 0% | 0 | 19% | 24% | 6% |
| Mammary + Lymphoma | 0% | 0 | 0 | 6% | 0% | 0% |
| Sarcoma | 4% | 5% | 0 | 0% | 24% | 6% |
| tumor number per mouse | 2.7 | 6.1 | 4.8 | 3.6 | 5.1 | 2.6 |
| Median survival (days) | 312 | 285 | 399 | 2.3 | 2.5 | 397 |
| % of lung metastases | 52% | 58% | 50% | 58% | 100% | 54% |
| loss of wtp53 allele | 11% | 18% | 0% | 38% | 95% | 0% |