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. 2019 Nov 27;9:17646. doi: 10.1038/s41598-019-54194-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The relative gene expression of claudin-1, occludin and IL-6 in the mouse colon. (A–C) The claudin-1 expression level in the colon was significantly lower in the model group than in the cell treatment group (*P = 0.045). The occludin expression level was higher in the IP group than in the IV group (*P = 0.032). IL-6 expression in the colon was significantly increased in the IV group (*P = 0.023). Occludin, VEGF-A, LC3A/B, and VEGFR-1 protein expression in mouse colon tissue. (D) After the treatment period, the expression of occludin, VEGF-A and VEGFR-1 in colon tissue was higher in the hUCMSC group than in the model group and the KM mUCMSC group and close to that in the normal control group. LC3A/B expression was lower in the hUCMSC and KM mUCMSC groups than in the other two groups.