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. 2019 Nov 27;10(12):898. doi: 10.1038/s41419-019-2133-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic representation of involvement of transcription factors Lmx1a, Nurr1 and Pitx3 in patterning of hiPSCs to dopaminergic neurons. b Experimental design for the use of viral vector to pattern hiPSCs to generate dopaminergic neurons. c–f Quantitative analysis of mRNA expression of infected rat transcription factors (rTFs) (c), endogenous human transcription factors (hTFs) (d), expression of endogenous hLmx1a in hiPSCs after transducing hiPSCs with AAV-HBA-rNurr1 and AAV-HBA-rPitx3-AU1 (e) and expression of endogenous human transcription factors (hTFs) after transducing hiPSCs with AAV-HBA-EGFP (f). Data represented as fold change ± SD as compared to their respective untreated control at the respective time point from three independent differentiations for each transcription factor.