Fig. 5. STAT3 inhibition attenuates liver fibrosis in mice.

C57/BL6 mice were subjected to the BDL procedure. Following the surgery, the mice were injected peritoneally with C188-9 as described in Methods. a Plasma ALT levels and AST levels. Expression levels of pro-fibrogenic genes were examined by qPCR (b) and western (c). d Picrosirius red and Masson’s trichrome stainings. e Hepatic hydroxylproline levels. N = 6–8 mice for each group.