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. 2019 Nov 27;9:17728. doi: 10.1038/s41598-019-53982-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cromolyn treatment does not alter microgliosis in the spinal cord of TgSOD1 mice. (a) Microglia of the lumbar spinal cord were visualized using the Iba1-specific antibody and DAB staining. (b) Quantifications of the percentage of Iba1⁺ cell area revealed no difference in the percentage of Iba1⁺ cell area in TgSOD1-Cromolyn mice compared to TgSOD1-Vehicle. There was a significant increase in the percentage of Iba1⁺ cell area in the spinal cord of both TgSOD1-Vehicle and TgSOD1-Cromolyn compared to both Wt groups as demonstrated by two-way ANOVA and Tukey’s post-hoc analysis. Wt-Vehicle (n = 19; light grey), Wt-Cromolyn (n = 17; dark grey), TgSOD1-Vehicle (n = 19; black), and TgSOD1-Cromolyn (n = 17; red). *Denotes differences between TgSOD1-Vehicle and Tg-SOD1-Cromolyn; ^{^}denotes differences between TgSOD1-Vehicle and Wt-Vehicle; ^#denotes differences between TgSOD1-Vehicle and Wt-Cromolyn; ^@denotes differences between TgSOD1-Cromolyn and Wt-Vehicle; ^%denotes differences between TgSOD1-Cromolyn and Wt-Cromolyn. ****p < 0.0001, the same statistical significance is associated with each symbol. Data are presented as median and interquartile ranges. Scale bar = 500 μm.