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. 2019 Nov 21;10:1346. doi: 10.3389/fphar.2019.01346

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Copyright © 2019 Spampinato, Bortolotto, Canonico, Sortino and Grilli

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of astrocyte-derived molecules in the adult neurogenic niche. In the permissive and instructive microenvironment of the neurogenic niche, astrocytes profoundly modulate adult neurogenesis through soluble signals. Neural stem/progenitor cells (NSC/NPC) self-renewal, neuronal commitment/differentiation, migration of neuroblasts, as well as survival and functional integration of newly born neurons can be affected by different classes of astrocytic-derived factors such as morphogens (i.e., Wnt3 and Wnt7), gliotransmitters (i.e., D-serine and glutamate), extracellular matrix (ECM) proteins [i.e., thrombospondin 1 (TSP-1)], and cytokines/chemokines/acute phase proteins [i.e., IL-1β, IL-6, and lipocalin-2 (LCN-2)].