Figure 3.

Dorsal hippocampal CA1 neurons degenerated in the Voa1 cKO mice. (A–C) Images were collected from two control mice and two Voa1 cKO mice. Representative coronal sections encompassing dorsal or ventral hippocampal areas were stained with cresyl violet. Squared hippocampal areas in (A) left panels were expanded in (B). Squared CA1 sectors in (B) or in (A) right panel were enlarged in (C) left or right panel. (D) Left and (D) right, hemispheric and hippocampal areas and densities of CA1 and CA3 cell body layers in coronal sections encompassing dorsal and ventral hippocampal areas respectively. Cell densities measures were made from adjacent three sections for each mouse. Data collected from seven Voa1 cKO mice and seven control mice. Note that hemispheric and dorsal hippocampal areas were decreased in the Voa1 cKO mice relative to the controls (independent t-test). Note also that the density of CA1 cell body layer was greatly decreased in the dorsal hippocampus of the Voa1 cKO mice.