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. 2019 Nov 27;9:17703. doi: 10.1038/s41598-019-54169-z

Figure 7.

Figure 7

FAM E3 activity on NS3Hel. Thermal denaturation curves of NS3Hel and Boltzmann fitting in the presence of DMSO (Control) or FAM E3. Tm of NS3Hel obtained after Boltzmann fitting is represented on the table (a). MicroScale Thermophoretic analysis of the interaction between FAM E3 and NS3Hel. Data from four experiments were normalized to the fraction of bound ligand and averaged. Kd constant was obtained after a sigmoidal shape fitting with the Hill function (black continuous line) (b). NTPase activity of ZIKV NS3Hel in the presence or absence of FAM E3 and using ATP as substrate (c).