Figure 1.

Nucleolar sequestration: the reversible remodeling of the nucleolus into an amyloid body. (A) During stimuli (heat shock or extracellular acidosis), the tripartite nucleolus undergoes a dramatic transformation into electron-dense fibrillar organization that characterizes an amyloid body. The fibers contain immobilized proteins in an amyloid-like state. After stimuli termination, an amyloid body is disaggregated and transforms back into the tripartite nucleolus. (B) The fibrillar amyloid bodies are distinct from the amorphous, electron-dense nucleolar caps (16 h cisplatin) or the electron-light nucleolar aggresomes (16 h MG132). FC, fibrillar component; DFC, dense fibrillar component; GC, granular component. Scale represents 1 µm. Amyloid body and nucleolar aggresome taken from (Audas, 2016) and (Kruger and Scheer, 2010), with permission.