Table 1.

List of the proteins whose activities have been reported to be regulated by nucleolar sequestration.

Protein symbol	Full name	Stimulus	Nucleolar response	Model system	Reference
Cdc14	Cell division cycle 14	Anaphase	Release	S. cerevisiae	(Shou, 1999) (Visintin et al., 1999)
Pch2	Pachytene checkpoint 2	Meiotic prophase arrest	Release	S. cerevisiae	(San-Segundo and Roeder, 1999)
MDM2	Murine double minute 2 homolog	Ribosomal stress DNA damage	Capture	Mammalian	(Weber, 1999) (Lohrum, 2000) (Bernardi, 2004)
hTERT	Human telomerase reverse transcriptase	Transformation, DNA damage Ionizing radiation	Release Capture	Mammalian	(Wong et al., 2002)
c-Myc	Proto-oncogene c-Myc	Proteasomal stress	Capture	Mammalian	(Arabi, 2003)
ADAR2	Adenosine deaminase that acts on RNA 2	Inhibition of rRNA synthesis	Release	Mammalian	(Sansam et al., 2003)
VHL	von Hippel Lindau tumor suppressor	Extracellular acidosis	Capture	Mammalian	(Mekhail, 2004)
RelA	p65 subunit of transcription factor NF-κB	Aspirin, serum withdrawal, UV-C radiation	Capture	Mammalian	(Stark and Dunlop, 2005) (Chen and Stark, 2017)
Polycomb	Polycomb	Cell differentiation	Capture	D. melanogaster	(Chen, 2005)
Hand1	Heart and neural crest derivatives expressed 1	Cell differentiation	Capture/Release	Mammalian	(Martindill et al., 2007)
Hsc70	Heat shock chaperone 70	Recovery from heat shock	Capture	Mammalian	(Banski, 2010)
Ulp1	Small ubiquitin-related modifier (SUMO) protease	Alcohol	Capture	S. cerevisiae	(Sydorskyy et al., 2010)
p53	Cell cycle regulator; tumor suppressor	Proteasomal inhibition (MG132)	Capture	Mammalian	(Kruger and Scheer, 2010) (Latonen, 2011)
Piwi	piRNA binding protein	Heat shock	Capture	D. melanogaster	(Mikhaleva, 2018)