Table 1.

Validation of shape-based models using different queries.

Kinase	Model	AUC	TOP 1%		TOP 5%		TOP 10%
			EF	BEDROC	EF	BEDROC	EF	BEDROC
CDPK1	I*	0.81	22.10	0.63	10.06	0.50	5.41	0.52
	II	0.83	20.99	0.58	7.40	0.41	4.74	0.45
	III	0.69	0.55	0.02	2.20	0.09	2.21	0.16
CDPK4	IV*	0.77	3.64	0.13	3.64	0.17	3.27	0.24
	V	0.72	3.64	0.13	3.15	0.15	3.27	0.23
	VI	0.74	3.64	0.13	3.39	0.15	3.27	0.23
PK6	VII*	0.95	26.15	0.77	13.64	0.68	8.46	0.74
	VIII	0.94	26.15	0.75	13.54	0.66	8.62	0.72
	IX	0.93	24.62	0.65	13.54	0.64	8.31	0.72

AUC, area under the ROC curve; EF, Enrichmenent Factor; BEDROC, Boltzmann-Enhanced Discrimination of ROC.

^*Selected model.