Table 2.
Levels of partial fecal metabolites in irritable bowel syndrome with predominant diarrhea patients and controls
| Metabolites | Prevalence of detection | IBS-D patients (μmol/g) | Controls (μmol/g) | P value |
| His | 93.3% | 0.0642 (0.0388, 0.1484)a | 0.2636 (0.0780, 0.3966) | 0.012 |
| Ala | 100.0% | 0.5095 (0.2826, 0.9183)a | 1.0118 (0.6135, 1.4335) | 0.041 |
| Tyr | 88.9% | 0.1024 (0.0173, 0.4527)a | 0.5665 (0.2436, 1.3447) | 0.018 |
| Phe | 97.8% | 0.1511 (0.0775, 0.3248)a | 0.3967 (0.1388, 0.7550) | 0.028 |
| Trp | 77.8% | 0.0323 (0.0001, 0.0826)a | 0.0834 (0.0170, 0.1759) | 0.046 |
| Val | 100.0% | 0.2710 (0.1208, 0.5729) | 0.3661 (0.2960, 1.0122) | 0.079 |
| Asp | 97.8% | 0.3086 (0.1797, 0.6904) | 0.4875 (0.1939, 0.6591) | 0.647 |
| Fumarate | 100.0% | 0.0042 (0.0026, 0.0108) | 0.0019 (0.0014, 0.0078) | 0.051 |
| Pyruvate | 100.0% | 0.0067 (0.0023, 0.0719) | 0.0071 (0.0022, 0.0882) | 0.718 |
| Butyrate | 100.0% | 4.3819 (2.4060, 9.0920) | 5.8539 (1.5193, 12.8616) | 0.613 |
| Isobutyrate | 100.0% | 6.8609 (0.5068, 8.9326) | 2.1277 (0.5470, 10.4635) | 0.962 |
| Valerate | 100.0% | 0.2024 (0.0331, 0.8245) | 0.2059 (0.0497, 1.2489) | 0.485 |
| Isovalerate | 100.0% | 0.1218 (0.0495, 0.3227) | 0.1661 (0.0416, 0.2581) | 0.866 |
| Hexanoate | 100.0% | 0.0254 (0.0189, 0.0513) | 0.0383 (0.0153, 0.0539) | 0.613 |
| Isohexanoate | 100.0% | 0.0127 (0.0060, 0.0246)a | 0.0070 (0.0023, 0.0106) | 0.028 |
| Amino acids | NA | 7.2873 (3.4177, 10.7709) | 8.0603 (6.1393, 12.3225) | 0.336 |
| SCFA | NA | 25.8082 (18.5826, 38.5067) | 26.8452 (5.7182, 70.6763) | 0.904 |
| Organic acids | NA | 26.6708 (20.0617, 38.5860) | 26.9449 (5.8047, 71.4057) | 0.866 |
a
P < 0.05 vs controls. The data are presented as the median (Q1, Q3). IBS-D: Irritable bowel syndrome with predominant diarrhea; SCFA: Short chain fatty acids; NA: Not applicable.