Figure 4.

Structure of TDG^82-308 bound to DNA with cadC^F flipped into the active site. The 2F_o–F_c electron density map, contoured at 1.0σ, is shown for cadC^F DNA and water molecules. Dashed lines represent hydrogen bonds, with interatomic distances (Å) shown. Water molecules contacting the carboxylate of cadC are labeled (a, b). The 2′-F substituent, colored cyan, is partially obscured by C2′, though its electron density is visible.