Table 2.
Baseline Illness Variables Based on Class Assignment
| Class 1: Predominantly euthymic (n=43) |
Class 2: Ill with significantly improving course (n=16) |
Class 3: Moderately euthymic (n=38) |
Class 4: Ill with moderately improving course (n=47) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | p | |
| KDRS | 21.7a | 11.9 | 23.1a,b | 8.6 | 26.3b,c | 11.3 | 29.2c | 10.3 | 0.007 |
| KMRS | 29.0 | 10.3 | 24.2 | 11.8 | 28.9 | 12.2 | 29.5 | 11.3 | 0.4 |
| Age of onset of any mood symptoms | 11.8 | 3.1 | 11.3 | 3.1 | 10.6 | 3.9 | 11.3 | 2.8 | 0.5 |
| Age of onset of MDE | 13.8 | 2.1 | 13.9 | 1.3 | 13.9 | 2.6 | 13.2 | 2.7 | 0.7 |
| Age of onset of H/ME | 14.1 | 2.5 | 13.7 | 2.7 | 13.8 | 3.0 | 13.5 | 2.8 | 0.8 |
| Prior number of hospitalizations | 1.5 | 3.1 | 1.2 | 1.6 | 0.9 | 1.2 | 1.3 | 2.0 | 0.7 |
| Prior number of MDE | 6.8 | 17.2 | 6.5 | 12.8 | 5.3 | 8.4 | 4.2 | 4.2 | 0.7 |
| Prior number of HME | 9.4 | 14.2 | 14.6 | 22.7 | 15.1 | 21.6 | 8.7 | 8.3 | 0.3 |
| N | % | N | % | N | % | N | % | p | |
| Bipolar I Disorder | 23 | 53.4 | 9 | 56.3 | 20 | 52.6 | 24 | 51.1 | 1.0 |
| Suicidal Ideation | 14 | 32.6a | 4 | 25.0a | 13 | 34.2a,b | 27 | 57.4b | 0.05 |
| Baseline Polarity | 0.1 | ||||||||
| Manic | 15 | 34.9 | 6 | 37.5 | 7 | 18.4 | 8 | 17.0 | |
| Hypomanic | 8 | 18.6 | 3 | 18.8 | 14 | 36.8 | 10 | 27.0 | |
| Depressive | 8 | 18.6 | 6 | 37.5 | 9 | 23.7 | 14 | 29.7 | |
| Mixed | 12 | 27.9 | 1 | 6.3 | 8 | 21.1 | 15 | 31.9 | |
| Comorbid Disorders | |||||||||
| Anxiety Disorder | 14 | 32.6 | 5 | 31.2 | 18 | 47.4 | 20 | 42.6 | 0.5 |
| ADHD | 14 | 32.6 | 6 | 37.5 | 11 | 28.9 | 17 | 36.2 | 0.9 |
| Conduct Disorder | 2 | 4.7 | 1 | 6.3 | 4 | 10.5 | 1 | 2.1 | 0.4 |
| ODD | 11 | 25.6 | 3 | 18.8 | 8 | 21.1 | 13 | 27.7 | 0.8 |
| Medications | |||||||||
| Any psychotropic | 38 | 88.4 | 14 | 87.5 | 33 | 86.8 | 36 | 76.6 | 0.4 |
| Antipsychotic | 28 | 65.1a,b | 8 | 50.0a | 30 | 78.9b | 25 | 53.2a | 0.06 |
| Antidepressant | 7 | 16.3 | 4 | 25.0 | 10 | 26.3 | 6 | 12.8 | 0.4 |
| Mood stabilizer | 31 | 72.1 | 10 | 62.5 | 31 | 81.6 | 31 | 66.0 | 0.4 |
| Lithium | 7 | 16.3 | 2 | 12.5 | 3 | 7.9 | 12 | 25.5 | 0.2 |
| Stimulant | 6 | 14.0 | 2 | 12.5 | 6 | 15.8 | 5 | 10.6 | 0.9 |
Note: Each superscript letter within a row denotes classes whose column proportions or means do not significantly differ from each other at the p<0.05 level. ADHD = attention-deficit/hyperactivity disorder; H/ME = hypomanic or manic episode; KDRS = K-SADS Depressive Rating Scale; KMRS = K-SADS Mania Rating Scale; MDE = major depressive episode; ODD = oppositional defiant disorder.