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. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: Nat Ecol Evol. 2019 Nov 11;3(12):1715–1724. doi: 10.1038/s41559-019-1018-8

Extended Data Fig. 5: Reduction potential of NAD(P)/FAD substitutes influences the size of expanded networks.

Extended Data Fig. 5:

We plotted the size (number of metabolites, y-axis) of expanded networks as a function of reduction potential of NAD(P)/FAD substitutes (x-axis) for different physico-chemical conditions with (a) no fixed carbon or thiols, (b) fixed carbon and no thiols, (c) thiols and no fixed carbon, and (d) both fixed carbon and thiols. (e) We plot the range of physiologically-feasible reduction potentials for classes of redox systems potentially relevant for early proto-metabolic systems, showing that dithiol/disulfide redox systems could potentially have enabled expansion under a variety of conditions.