Table 1.
Association analysis of two TP53 gene polymorphisms with keloid in Caucasians.
| Polymorphisma (position) | Alleleb (1/2) |
Cases 1/2 (%) |
Controls 1/2 (%) |
p | Cases (n = 86) | Controls (n = 100) | p c | OR (95% CI)d | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11 | 12 (%) | 22 | 11 | 12 (%) | 22 | |||||||
| rs1042522 (chr. 17: 7579472) | G/C | 137/35 (80/20) | 143/57 (72/28) | 0.690 | 54 (63) | 29 (34) | 3 (3) | 51 (51) | 41 (41) | 8 (8) | 0.070 | 0.63 (0.39–1.04) |
| rs17878362 (chr. 17: 7579690) | A1/A2 | 152/20 (88/12) | 172/28 (86/14) | 0.496 | 67 (78) | 18 (21) | 1 (1) | 73 (73) | 26 (26) | 1 (1) | 0.485 | 0.80 (0.42–1.51) |
aSNP position was indexed to the NCBI build 37 (GRCh37.p13). bAllele 1 and allele 2 were defined as the nonsusceptible allele or the risk allele, respectively. cp values for logistic regression in additive mode of inheritance of the risk allele. dORs and CIs were calculated using the nonsusceptible allele as a reference.