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. 2019 Aug 29;9(1):61–78. doi: 10.1016/j.jcmgh.2019.08.008

Figure 7.

Figure 7

miR-148a down-regulation during chief cell transdifferentiation process. (A) Fluorescence in situ hybridization for miR-148a (red) and immunofluorescence staining for GSII (green) and DAPI (blue). miR-148a was expressed in chief cells treated with xCT inhibitor, sulfasalazine, only. With 3 days of L635 co-treatment with sulfasalazine, miR-148a expression was lost. (B) Quantitation of relative miR-148a staining intensity. Mann-Whitney U test, *P < .05. (C) Fluorescence in situ hybridization for miR-148a (red) and immunofluorescence staining for GSII (green) and DAPI (blue). In xCT knockout (KO) mice, miR-148a was expressed in chief cells. With 3 days of L635, miR-148a expression was decreased in xCT KO mice. (D) Quantitation of relative miR-148a staining intensity. Mann-Whitney U test, *P < .05.