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. 2019 Nov 23;5(11):e02882. doi: 10.1016/j.heliyon.2019.e02882

Table 1.

Mouse neuroinvasiveness of recombinant JEV strains.

Experiment no. Virus Dose (pfu/mouse) Survivala Mean time to death (day) P valueb (vs Mie/41/2002) P valueb (vs Muar) P valueb (vs rJEV-EMuar-M41) P valueb (vs rJEV-EXZ0934-M41) P valueb (vs rJEV-5NCMMuar-M41)
1 Mie/41/2002 104 8/8 - - <0.001*
Muar 104 0/8 7.8 <0.001* -
rJEV-5NCMEMuar-M41 104 0/8 7.8 <0.001* 1.0
rJEV-NS1-3Muar-M41 104 6/8 16.0 0.1435 <0.001*
rJEV-NS4A-5Muar-M41 104 8/8 - 1.0 <0.001*
rJEV-NS5-3NMuar-M41 104 6/8 15.6 0.1435 <0.001*



2 Mie/41/2002 104 8/8 - -
rJEV-5NCMEMuar-M41 104 0/8 6.4 <0.001*
rJEV-5NCMMuar-M41 104 1/8 8.5 <0.001*
rJEV-EMuar-M41 104 1/8 8.6 <0.001*
rJEV-5NCMEXZ0934-M41 104 0/8 6.3 <0.001*
rJEV-5NCMXZ0934-M41 104 2/8 10.9 0.002*
rJEV-EXZ0934-M41 104 1/8 10.1 <0.001*
rJEV-ES123H-M41 104 3/8 11.3 0.009*



3 Mie/41/2002 103 9/10 17.0 -
rJEV-ES123H-M41 103 10/10 - 0.3173
Mie/41/2002 105 5/10 12.6 -
rJEV-ES123H-M41 105 0/10 6.8 0.007*



4 rJEV-EMuar-M41 104 3/10 10.6 -
rJEV-EMuar-H123S-M41 104 1/10 9.0 0.4773
rJEV-EXZ0934-M41 104 3/10 10.5 -
rJEV-EXZ0934-H123S-M41 104 4/10 13.0 0.38



5 rJEV-5NCMMuar-M41 104 2/8 11.0 -
rJEV-CMuar-M41 104 7/8 16.8 0.021
rJEV-prMMuar-M41 104 2/8 11.8 0.9093
a

No. of mice surviving/no. of mice inoculated.

b

P value relative to Mie/41/2002, Muar, rJEV-EMuar-M41, rJEV-EXZ0934-M41, and rJEV-5NCMMuar-M41 by log-rank test. Asterisks indicate statistical significance (*, p < 0.01).