Table 5.
Effect of “c” in the utility function on accuracy of optimal dose selection in the 2D TEQR design.
| Scenario | Accuracy of Optimal Dose Selection in the 2D TEQR Design when c = 1 | Accuracy of Optimal Dose Selection in the 2D TEQR Design when c = 0.5 | Accuracy of Optimal Dose Selection in the 2D TEQR Design when c = 0.1 |
|---|---|---|---|
| 2 | 66.5% | 58.4% | 49.9% |
| 3 | 65.0% | 65.9% | 65.8% |
| 4* | 49.3% (DL1) | 39.2% (DL1) | 29.5% (DL1) |
| 30.8% (DL2) | 32% (DL2) | 27.4% (DL2) | |
| 5 | 47.5% | 43.3% | 35.6% |
*For Scenario 4, the results are shown for both dose level 1 (DL1) and dose level 2 (DL2), based on Table 3, where dose level 2 is the true optimal dose but dose level 1 is chosen most frequently as the optimal dose by the 2D TEQR and TEPI designs.