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. 2019 Aug 14;9(1):1–13. doi: 10.1016/j.jcmgh.2019.08.003

Figure 3.

Figure 3

PERK signaling maintains the high baseline expression of ASNS in the pancreas. (A) Western blot for the components of the PERK signaling pathway in mouse tissues (n = 3). (B) qPCR of ATF4 in mouse tissues (n = 3; **P < .01). (C) Treatment of the mouse pancreatic 266-6 acinar cell with the PERK inhibitor GSK2606414 (PERKi; 10 μmol/L) for 16 hours led to reduced baseline ASNS expression (n = 3; **P < .01). Bip, Binding immunoglobulin protein; p-eIF2a, phosphorylated eIF2a; p-PERK, phosphorylated PERK.