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. 2019 Oct 23;15:320–332. doi: 10.1016/j.omtm.2019.10.007

Figure 2.

Figure 2

Identification of AAV-S and AAV-F after Two Rounds of In Vivo Selection for Brain Transduction

Donut charts indicate the frequency of particular peptide inserts determined by NGS. (A) Chart of round 2 vector sequenced after production but before intravenous injection. (B) Chart of peptide frequency appearing in iTransduce isolation after round 2 injection. “Others” indicates sequence variants appearing as less than 1% of the total pool (in A, variants isolated after the round 2 screen are also highlighted, appearing at less than 1%). The asterisk (*) indicates a stop codon.