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Overall survival analysis for 20 hub genes from method 1: (a) CCNB1, (b) CCNB2, (c) ESPL1, (d) CDC45, (e) FANCI, (f) MCM10, (g) CDT1, (h) PRC1, (i) MKI67, (j) JUN, (k) ASP1B, (l) CENPM, (m) SGOL1, (n) CDC25A, (o) CDK6, (p) CDCA3, (q) TACC3, (r) TROAP, (s) CDK4, and (t) BLM. For the 20 hub genes, only (j) JUN (HR = 1.4, p=0.041) and (o) CDK6 (HR = 1.5, p=0.013) showed statistical significance that higher expression patients indicated poor overall survival.
