Table 3.

Most important pathways based on the metabolic fingerprint.

Pathways mainly affected in CAA patients
Pathway name	p value	False discovery rate (FDR)	Metabolites belonging to the pathway
Purine nucleotide cycle	0,004	0,125	Hypoxanthine, urea, uric acid, glycine, inositol, urea, 1,2-propanediol
Amino sugar and nucleotide sugar metabolism	0,009	0,125	Glucose, pyruvic acid, N-acetylneuraminic acid
Pentose phosphate pathway	0,009	0,125	Glucose, pyruvic acid, phosphate, ethanolamine
Glycolysis and gluconeogenesis pathways	0,022	0,242	Lactic acid, pyruvic acid, glucose, citric acid, succinic acid