Figure 8.

Histopathological analysis of ankle joints stained with H&E. (a) Healthy control showing normal structure with small joint space; (b) arthritic control showing very large joint space (A), destruction of cartilage (B), bone erosion (C), and cellular infiltration (D); (c) diclofenac 5 mg/kg treated, (d) aqueous extract (AE) 250 mg/kg treated, and (e) ethanolic extract (EE) 250 mg/kg treated showing a decrease in joint space, a reduction of cells infiltration and reduction of cartilage destruction.