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. 2019 Nov 27;85(24):e01692-19. doi: 10.1128/AEM.01692-19

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Copyright © 2019 Takeda et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Overall structure of the AA12 domain of CcPDH. (A) Domain organization of CcPDH and CDH from Phanerochaete chrysosporium. Abbreviations: AA3_1, auxiliary activity (AA) family 3 subfamily 1 domain (a flavoprotein containing flavin adenine dinucleotide [FAD]); AA8, AA family 8 domain containing a b-type cytochrome; AA12, AA family 12 domain (a PQQ-dependent dehydrogenase domain); CBM1, family 1 carbohydrate-binding module. (B) Overall structure of the holo-AA12 domain of CcPDH. The bound calcium ion is shown as a green sphere. The disulfide bonds (Cys244-Cys302, Cys492-Cys525, and Cys611-Cys619), acetate ion, and ethylene glycol molecule are shown as stick models. (C) Representation highlighting the active site at the PQQ (magenta) and the calcium ion (green) in the holo-AA12 domain, with the 2F_o − F_c electron density (where F_o and F_c are the observed and the calculated structure factors, respectively) calculated to be 1.3 Å. The atom nomenclature is indicated.