Table 2.
Biometric and hemodynamic parameters of high-dose liraglutide groups with/without 10% glucose intake
| High-dose liraglutide treatment (J2N-k) | High-dose liraglutide treatment with 10% glucose intake (J2N-k) | |
|---|---|---|
| (n = 13) | (n = 12), (n = 5 for LV pressure) | |
| Biometry | ||
| Body weight, g | 107 ± 2.8 | 120.2 ± 2.8† |
| Heart, g | 0.72 ± 0.04 | 0.61 ± 0.03* |
| Heart/BW, mg/g | 6.7 ± 0.4 | 5.1 ± 0.2† |
| Lung, g | 0.85 ± 0.09 | 0.71 ± 0.03 |
| Lung/BW, mg/g | 7.9 ± 0.9 | 5.9 ± 0.2† |
| Echocardiography | ||
| HR, beats/min | 376 ± 19 | 399 ± 8 |
| LVEDD, mm | 7.4 ± 0.1 | 7.1 ± 0.1 |
| LVESD, mm | 6.3 ± 0.2 | 5.7 ± 0.1† |
| LV ejection, % | 0.35 ± 0.02 | 0.45 ± 0.02† |
| LV FS, % | 0.15 ± 0.01 | 0.20 ± 0.01* |
| LV AW, mm | 0.67 ± 0.01 | 0.79 ± 0.03† |
| LV PW, mm | 0.79 ± 0.02 | 0.87 ± 0.05† |
| Intracardiac pressure | ||
| Positive dP/dt, mmHg/s | 2501 ± 290 | 4699 ± 981* |
| Negative dP/dt, mmHg/s | − 1700 ± 171 | − 2128 ± 357 |
| EDP, mmHg | 13.8 ± 2.8 | 12.8 ± 2.36 |
| Max pressure, mmHg | 66.1 ± 5.5 | 76.2 ± 6.31 |
| Min pressure, mmHg | 9.4 ± 2.0 | 7.3 ± 0.87 |
All values were expressed as mean ± SEM. *p > 0.05, †p > 0.005