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. 2019 Nov 27;18:163. doi: 10.1186/s12933-019-0967-1

Table 3.

Relationship between hypoglycemia and mortality in beta blocker subgroups

Non-recipients of beta blockers  Carvedilol recipients  Selective beta blocker recipients 
OR 95% CI  p-value  OR  95% CI  p-value  OR  95% CI  p-value 
Odds ratio for mortality in patients with vs. those without hypoglycemia (< 3.9 mmol/L) within 24 h of admission
 Unadjusted model  2.40 1.56–3.71  < 0.001  0.83  0.25–2.81  0.77  1.60  0.74–3.46  0.23 
 Adjusted model  2.10 1.15–3.86  0.016  0.79  0.15–4.10  0.78  1.67  0.54–5.16  0.37 
Odds ratio for mortality in patients with vs. those without hypoglycemia (< 3.9 mmol/L) overall 
 Unadjusted model  2.21 1.60–3.04  < 0.0001  1.18  0.54–2.60  0.68  2.17  1.08–4.37  0.03 
 Adjusted model  1.80 1.16–2.80  0.009  1.55  0.49–4.95  0.46  4.89  1.76–13.56  0.002 
Odds ratio for mortality in patients with vs. those without hypoglycemia (< 2.2 mmol/L) overall 
 Unadjusted model  4.63 2.52–8.52  < 0.0001 1.76 0.40–7.67  0.45 6.42 2.73–15.1 < 0.0001
 Adjusted model  3.74 1.48–9.46  0.005  1.94  0.36–10.3  0.44 10.6 3.27–34.3 < 0.0001

Adjusted model includes age, gender, race, body mass index*, surgery service, admission glucose*, admission creatinine*, hospital length of stay*, basal insulin, heart failure, cardiovascular service, statin, aspirin, ACE/ARB and hypoglycemia (< 70 mg/dL within 24 h, < 70 during entire hospitalization, or < 40 mg/dL during entire hospitalization. * log transformed values