Table 2.
Effect of different PEEP levels on hemodynamics. Data are shown as mean ± SD
| PEEP(cmH2O) | ||||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 2 | 4 | 6 | 8 | 10 | 12 | ||
| SBP (mmHg) | 0 | 119.1 ± 9.9 | 120.2 ± 8.4 | 119.9 ± 9.2 | 121.3 ± 6.6 | 121.9 ± 9.4 | 120.8 ± 9.2 | 122.6 ± 9.1 |
| 1 | 151.6 ± 13.2 | 152.6 ± 9.4 | 154.2 ± 10.0 | 146.1 ± 14.2 | 142.8 ± 14.4 | 139.8 ± 15.3bc | 137.1 ± 14.1abc | |
| DBP (mmHg) | 0 | 67.4 ± 5.3 | 68.6 ± 6.7 | 67.9 ± 5.7 | 69.6 ± 6.2 | 70.5 ± 6.9 | 69.7 ± 7.5 | 69.6 ± 8.7 |
| 1 | 82.0 ± 12.0 | 84.1 ± 11.4 | 82.5 ± 12.9 | 77.4 ± 13.1 | 76.0 ± 12.4 | 73.3 ± 13.8 | 72.2 ± 11.7b | |
| MABP (mmHg) | 0 | 84.7 ± 3.7 | 85.7 ± 4.3 | 85.6 ± 4.3 | 86.8 ± 4.9 | 87.6 ± 4.9 | 86.7 ± 4.6 | 87.1 ± 5.4 |
| 1 | 105.1 ± 10.1 | 107.6 ± 7.9 | 106.0 ± 9.7 | 100.2 ± 10.9 | 98.1 ± 10.4b | 95.3 ± 11.5bc | 93.8 ± 10.0abc | |
| CVP (mmHg) | 0 | 7.2 ± 1.2 | 7.4 ± 1.2 | 7.6 ± 1.2 | 7.8 ± 1.3 | 8.0 ± 1.2 | 8.2 ± 1.3 | 8.4 ± 1.3 |
| 1 | 8.1 ± 3.3 | 8.4 ± 3.1 | 9.0 ± 4.2 | 8.7 ± 2.6 | 9.0 ± 2.9 | 9.1 ± 2.8 | 9.3 ± 2.9 | |
| ScvO2 (%) | 0 | 68.4 ± 7.3 | 68.6 ± 5.8 | 69.3 ± 6.0 | 69.9 ± 7.4 | 71.3 ± 5.7 | 70.4 ± 8.0 | 72.0 ± 6.6 |
| 1 | 67.3 ± 8.5 | 69.3 ± 8.9 | 70.8 ± 7.6 | 67.8 ± 5.7 | 65.3 ± 6.4 | 64.0 ± 5.7c | 61.9 ± 6.2cd | |
| HR (bpm) | 0 | 82.6 ± 12.5 | 82.9 ± 12.7 | 83.3 ± 12.9 | 83.8 ± 13.5 | 82.1 ± 13.2 | 82.6 ± 13.3 | 82.7 ± 12.8 |
| 1 | 80.2 ± 12.5 | 78.5 ± 12.2 | 76.9 ± 10.4 | 80.9 ± 12.7 | 82.7 ± 10.7 | 85.1 ± 9.8 | 88.2 ± 11.5c | |
| Ppeak (cmH2O) | 0 | 20.4 ± 4.9 | 21.5 ± 4.6 | 22.3 ± 4.4 | 23.6 ± 4.5 | 24.6 ± 4.4 | 25.7 ± 4.5a | 27.3 ± 4.8ab |
| 1 | 20.8 ± 4.1 | 21.8 ± 4.3 | 23.3 ± 4.6 | 24.6 ± 5.1 | 26.1 ± 4.9a | 27.4 ± 4.8ab | 29.3 ± 4.7abc | |
| Pmean (cmH2O) | 0 | 10.1 ± 2.1 | 11.1 ± 2.2 | 11.9 ± 2.3 | 13.1 ± 2.5a | 13.9 ± 2.2ab | 15.1 ± 2.4abc | 16.2 ± 2.7abcd |
| 1 | 10.3 ± 2.3 | 11.2 ± 2.0 | 12.3 ± 2.1 | 13.7 ± 2.2ab | 14.7 ± 2.1abc | 16.0 ± 2.2abcd | 17.5 ± 2.2abcde | |
| VT (ml) | 0 | 644.6 ± 95.3 | 649.7 ± 96.8 | 654.0 ± 96.1 | 651.9 ± 94.3 | 642.6 ± 106.2 | 646.3 ± 106.4 | 645.3 ± 107.2 |
| 1 | 584.0 ± 119.1 | 587.0 ± 118.3 | 591.1 ± 114.1 | 589.6 ± 115.4 | 586.9 ± 117.7 | 587.4 ± 116.3 | 585.3 ± 117.3 | |
| MV (L/min) | 0 | 11.7 ± 1.6 | 11.7 ± 1.6 | 11.8 ± 1.6 | 11.8 ± 1.5 | 11.6 ± 1.8 | 11.7 ± 1.8 | 11.7 ± 1.9 |
| 1 | 10.5 ± 2.1 | 10.6 ± 2.1 | 10.8 ± 2.0 | 10.7 ± 2.0 | 10.8 ± 2.1 | 10.9 ± 2.0 | 10.7 ± 2.0 | |
| SpO2 | 0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 |
| (%) | 1 | 99.9 ± 0.5 | 99.9 ± 0.3 | 100.0 ± 0.2 | 100.0 ± 0.2 | 100.0 ± 0.2 | 100.0 ± 0.2 | 99.9 ± 0.5 |
SBP Systolic blood pressure, DBP Diastolic blood pressure, MABP Mean arterial blood pressure, CVP Central venous pressure, ScvO2 Central venous oxygen saturation, HR Heart rate, Ppeak Peak airway pressure, Pmean Mean airway pressure, VT Tidal volume, MV Minute ventilation volume, SpO2 Peripheral oxygen saturation; 0: Control group; 1: Hypertension group;
aP < 0.05, compared with PEEP 2 cm H2O: bP < 0.05, compared with PEEP 4 cm H2O: cP < 0.05, compared with PEEP 6 cm H2O: dP < 0.05, compared with PEEP 8 cm H2O: eP < 0.05. In the same group of blood pressure, compared with PEEP 0 cm H2O: aP < 0.05, compared with PEEP 2 cm H2O: bP < 0.05, compared with PEEP 4 cm H2O: cP < 0.05, compared with PEEP 6 cm H2O: dP < 0.05, compared with PEEP 8 cm H2O: eP < 0.05