Figure 3.

Structure of mdPrP. (A) Ensemble of 20 lowest energy structures of mdPrP (residues form Ala¹²³ to Ala²³³). α-Helices and 3₁₀-helix are colored green, β-sheets are colored magenta, and loops are colored champagne pink. (B) Well-defined region between residues Ala¹²³ and Tyr¹³¹. (C) Residues from Ala¹²³ to Tyr¹³¹ involved in the formation of α-helical turn (Val¹²⁵–Leu¹²⁸) and γ-turn (Leu¹²⁸–Gly¹³⁰). (D) Hydrophobic pocket in the proximity of the β2−α2 loop and the C-terminus of the α3 helix. (E) 3₁₀-Helix from residues Pro¹⁶⁸ to Tyr¹⁷² inside the β2−α2 loop. Residues are presented as sticks in champagne pink and the hydrogen bonds in panels (C,E) are shown as dashed lines in cyan.