Table 2.
Histology evaluation of bladder tissues from individual mice among treatment groups with normalized total radiant efficiency values of bladder to blood by IVIS detection system
| Mouse # | Inflammation (Infl) | Hyperplasia (Hyp) | Carcinoma in situ (CIS) | Carcinoma (CA) | Normalized Total Radiant Efficiency of bladder to blood by IVIS | |
|---|---|---|---|---|---|---|
| Group 1 18wks H2o | 1–1 | 1 L | 0 | 0 | 0 | 1.50 |
| 1–2 | 0 | 1 F | 0 | 0 | 2.36 | |
| 1–3 | 3 LF | 1 F | 0 | 0 | 5.47 | |
| 1–4 | 0 | 0 | 0 | 0 | 2.53 | |
| 1–5 | 0 | 0 | 0 | 0 | 2.72 | |
| 1–6 | 0 | 0 | 0 | 0 | 3.55 | |
| 1–7 | 0 | 0 | 0 | 0 | 1.88 | |
| 1–8 | n/a | n/a | n/a | n/a | 2.89 | |
| 1–9 | n/a | n/a | n/a | n/a | 3.46 | |
| 1–10 | 0 | 0 | 0 | 0 | 2.89 | |
| Group 2 12wks BBN | 2–1a | n/a | n/a | n/a | n/a | n/a |
| 2–2 | 2 NPL 1 M | 0 | 0 | 0 | 7.11 | |
| 2–3 | 1 NL | 1 M | 0 | 0 | 10.50 | |
| 2–4 | 3 LP 1 M | no urothelium | no urothelium | no urothelium | 11.68 | |
| 2–5 | 3 LP | no urothelium | no urothelium | no urothelium | 8.82 | |
| 2–6 | 2 NPL rareM | 2 L | Yes | Yes | 6.64 | |
| 2–7 | 2 LP 1 M | 1 M | 0 | 0 | 12.93 | |
| 2–8 | 1 L | minimal urothelium | 0 | 0 | 10.62 | |
| 2–9 | 1 NPL 1 M | 1 M | 0 | 0 | 4.27 | |
| 2–10 | 1 NLP 2 M | 1 M | Yes | Yes | 8.31 | |
| Group 3 18wks BBN | 3–1 | 1 LPNM | 1 D | Yes | 0 | 7.81 |
| 3–2 | 3 PNL 1 M | 2 M | Yes | Yes | 35.41 | |
| 3–3 | 2 LP 1 M | 2 | 0 | 0 | 24.88 | |
| 3–4 | 3 LN 1 M | 2 | Yes | 0 | 5.84 | |
| 3–5 | 2 LM | 1 | 0 | Yes | 47.67 | |
| 3–6 | 2 LM | 1 | 0 | Yes | 5.77 | |
| 3–7 | 2 LNM | 1 | 0 | Yes | 25.67 | |
| 3–8 | 2 LNM | 2 | 0 | Yes | 15.18 | |
| 3–9 | 3 LNPM | 1 | 0 | Yes | 23.81 | |
| 3–10 | 2 LN 1 M | 1 D | 0 | 0 | 13.43 |
Notes: n/a - No bladder tissue was available for histology evaluation; aMouse#2–1 died before the end of experiment with unknown cause of death