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. 2019 Nov 19;9:1176. doi: 10.3389/fonc.2019.01176

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Copyright © 2019 Zhang, Li, Tan, Liu, Jiang, Liu, Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-9-5p inhibits GBM cell growth through cell cycle arrest in vitro. (A) Expression of miR-9-5p in U251 cell transfected with miRNA. (B,C) CCK-8 (B) and EdU (C) show that high expression of miR-9-5p inhibits cell growth while low expression leads to the opposite effect. (D) Cell cycle is arrested in cells with high expression of miR-9-5p analyzed by Flow cytometry. (E) Over expression of miR-9-5p leads to down regulation of FOXP2 (p = 0.001) and up regulation of p21 (p = 0.001); while the inhibited miR-9-5p leads to up regulation of FOXP2 (p = 0.003) and down regulation of p21 (p < 0.001).