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Mechanisms of resistance to CAR T-cell therapy. (A) CAR T cells exerting an antitumor effect under normal circumstances. (B) Mechanisms of resistance to CAR T-cell therapy with respect to CAR T cells. (C) Mechanisms of resistance to CAR T-cell therapy with respect to tumor cells. (D) Mechanisms of resistance to CAR T-cell therapy with respect to the tumor microenvironment.
