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miR-155 regulated proliferation and senescence through the SIRT1/FoxO-1/P53/P21-dependent pathway. (A) The proliferation effects of miR-155 downregulation were mostly abolished after SIRT1 knockdown. (B) SA β-Gal activity and Western blot analysis of SMP-30 protein levels in HUVECs after miR-155 knockdown. (n=3, * p<0.05 vs. untreated, # p<0.05 vs. NC+TNF-α, & p<0.05 vs. miR-155 inhibitor+TNF-α, @ p<0.05 vs. simock+TNF-α)
