Table 3.
Disease free survival and overall survival of various clinicopathological factors and studied mutations
| Variables | 30 month disease free survival (%) | p value | 30 month overall survival (%) | p value |
|---|---|---|---|---|
| Age (year) | 0.001* | 0.003* | ||
| < 46 | 36.4 | 45.5 | ||
| > 46 | 75.0 | 87.5 | ||
| Site of tumor | 0.641 | 0.665 | ||
| Tongue | 61.5 | 69.2 | ||
| Buccal mucosa | 50.0 | 66.7 | ||
| Lower alveolus | 66.7 | 50.0 | ||
| Upper alveolus | 100 | 100 | ||
| Lower lip | 50.0 | 100 | ||
| HPE size (cm) | 0.846 | 0.720 | ||
| < 4 | 54.3 | 74.3 | ||
| ≥ 4 | 63.6 | 45.5 | ||
| Lymph node (HPE) | 0.250 | 0.021* | ||
| Positive | 42.9 | 42.9 | ||
| Negative | 62.5 | 78.1 | ||
| Extra nodal extension (ENE) | 0.464 | 0.997 | ||
| Present | 42.9 | 71.4 | ||
| Absent | 59.0 | 66.7 | ||
| Depth of invasion (mm) | 0.731 | 0.008* | ||
| < 5 | 50.0 | 100 | ||
| ≥ 5, > 10 | 58.3 | 79.2 | ||
| < 10 | 55.6 | 44.4 | ||
| Vascular invasion | 0.018* | 0.042* | ||
| Positive | 23.1 | 38.5 | ||
| Negative | 69.7 | 78.8 | ||
| PNI | 0.196 | 0.134 | ||
| Positive | 40.0 | 50.0 | ||
| Negative | 69.2 | 80.8 | ||
| Adjuvant RT | 0.731 | 0.042* | ||
| Yes | 52.6 | 47.4 | ||
| No | 59.3 | 81.5 | ||
| Mutations | ||||
| TP53 | 0.176 | 0.082 | ||
| Present | 47.4 | 52.6 | ||
| Absent | 63.0 | 77.8 | ||
| CDKN2A | 0.320 | 0.431 | ||
| Present | 72.7 | 81.8 | ||
| Absent | 51.4 | 62.9 | ||
| PIK3CA | 0.148 | 0.221 | ||
| Present | 100 | 100 | ||
| Absent | 53.5 | 65.1 | ||
| HRAS | 0.629 | 0.761 | ||
| Present | 62.5 | 75.0 | ||
| Absent | 55.3 | 65.8 |
*statistically significant