Fig. 6.

DNA damage signalling and repair gene expression in irradiated isogenic FaDu, FaDu-RR, and 2A3 cells. a Gene expression in 5 Gy-irradiated parental FaDu cells relative to non-irradiated FaDu cells; b gene expression in 5 Gy-irradiated radioresistant FaDu-RR relative to non-irradiated FaDu-RR cells; c gene expression in 5 Gy-irradiated radioresistant 2A3 cells relative to non-irradiated 2A3 cells. Volcano plots show the fold change in gene expression and statistical significance (p-value). The horizontal line shows the statistical significance threshold (p-value < 0.05). Two vertical dashed lines show the threshold of over-expressed (right) and under-expressed genes (left). The solid vertical line shows no change in gene expression. Symbols represent the mean gene expression of each tested gene in 5 Gy-irradiated cells relative to pertinent non-irradiated cells from three independent experiments