Table 2.

Subgroup analysis of the relationship between PLR and OS, PFS, DFS, and CSS in UC

Factors	No. of studies	Effect model	HR (95%CI)	p	Heterogeneity
					I2(%)	Ph
OS
All	9	Random	1.23 (0.95–1.59)	0.124	70.7	0.001
Sample size
≤200	6	Random	1.37 (0.87–2.15)	0.174	78.7	<0.001
>200	3
Tumor type
UTUC	3	Random	1.47 (0.70–3.12)	0.309	80.2	0.006
BC	6	Fixed	1.002 (1.000–1.004)	0.049	36.1	0.166
Treatment
RC	4	Random	1.27 (0.83–1.95)	0.266	56.8	0.074
RNU	2	Fixed	2.13 (1.48–3.07)	<0.001	47.6	0.167
TURB	2	Fixed	0.95 (0.74–1.22)	0.666	0	0.409
NUx	1	–	0.66 (0.32–1.35)	0.253	–	–
PFS
All	7	Random	1.81 (1.28–2.56)	0.001	60.1	0.020
Sample size
≤200	4	Random	1.92 (1.14–3.26)	0.015	58	0.067
>200	3	Random	1.68 (1.03–2.75)	0.040	60.1	0.020
Tumor type
UTUC	6	Random	1.67 (1.2–2.31)	0.002	54.8	0.050
BC	1	–	4.09 (1.52–11.03)	0.005	–	–
DFS
All	6	Fixed	1.69 (1.31–2.16)	<0.001	0.6	0.412
Sample size
≤200	3	Fixed	1.35 (0.94–1.95)	0.103	0	0.573
>200	3	Fixed	2.05 (1.45–2.90)	<0.001	0	0.535
Tumor type
UTUC	5	Fixed	1.54 (1.17–2.02)	0.002	0	0.672
BC	1	–	2.74 (1.46–5.14)	0.002	–	–
Treatment
RNU	4	Fixed	1.54 (1.17–2.04)	0.002	0	0.504
TURB	1	–	2.74 (1.46–5.14)	0.002	–	–
NUx	1	–	1.50 (0.47–4.80)	0.499	–	–
CSS
All	5	Fixed	1.000 (0.998–1.002)	0.919	0	0.859
Sample size
≤200	2	Fixed	1.000 (0.998–1.002)	0.923	0	0.635
>200	3	Fixed	1.23 (0.82–1.85)	0.311	0	0.968
Tumor type
UTUC	1	–	1.20 (0.37–3.86)	0.757	–	–
BC	4	Fixed	1.000 (0.998–1.002)	0.919	0	0.748
Treatment
RC	2	Fixed	1.000 (0.998–1.002)	0.923	0	0.635
TURB	2	Fixed	1.24 (0.80–1.91)	0.334	0	0.801
NUx	1	–	1.20 (0.37–3.86)	0.757	–	–