. Author manuscript; available in PMC: 2019 Nov 28.

Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 19;1092:447–452. doi: 10.1016/j.jchromb.2018.06.040

Table 3:

Summary of intra-day and inter-day accuracy and precision of LC-MS/MS assay for the determination of valacyclovir (VACV) and acyclovir (ACV) in mouse and human plasma. CV: coefficient of variation.

Analyte and Matrix	Concentrations (nM)	Intra-day (n=5)		Inter-day (n=5)
Analyte and Matrix	Concentrations (nM)	Accuracy (%)	Precision (CV%)	Accuracy (%)	Precision (CV%)
ACV in mouse plasma	10; 200; 2000	99.4%; 97.3%; 101.9%	5.5%; 8.0%; 7.6%	98.9%; 96.5%; 104.1%	8.9%; 5.9%; 6.5%
ACV in human plasma	10; 200; 2000	108.1%; 94.8%; 105.8%	4.2%; 2.6%; 5.0%	107.8%; 96.0%; 104.0%	3.8%; 3.0%; 5.5%
VACV in mouse plasma	10; 200; 2000	102.9%; 106.8%; 100.6%	5.2%; 3.7%; 2.1%	105.4%; 104.4%; 102.2%	5.4%; 4.1%; 3.7%
VACV in human plasma	10; 200; 2000	104.1%; 102.4%; 101.6%	5.9%; 2.0%; 4.2%	108.7%; 101.1%; 102.1%	6.4%; 2.8%; 4.5%