. Author manuscript; available in PMC: 2019 Nov 28.

Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 19;1092:447–452. doi: 10.1016/j.jchromb.2018.06.040

Table 5:

Stability of valacyclovir (VACV) and acyclovir (ACV) in mouse and human plasma under different conditions (n=4). QC: quality control; SD: standard deviation.

ACV/VACV stability	Relative mean ± SD (%) of QC samples (10, 2000 nM)
ACV/VACV stability	ACV in mouse plasma	ACV in human plasma	VACV in mouse plasma	VACV in human plasma
Bench (4 hr at room temperature)	98.3 ± 5.4; 99.5 ± 7.8	95.3 ± 2.9; 96.5 ± 8.5	76.1 ± 4.9; 79.0 ± 6.7	91.1 ± 4.7; 94.0 ± 9.0
Bench (4 hr on ice)	97.6 ± 5.4; 96.8 ± 2.5	98.6 ± 2.4; 95.7 ± 6.8	94.5 ± 5.6; 99.4 ± 6.4	95.0 ± 3.1; 98.4 ± 3.5
Autosampler (4 °C for 24 hr)	103.0 ± 8.6; 99.4 ± 4.3	104.2 ± 2.6; 100.1 ± 4.8	102.1 ± 4.1; 99.4 ± 3.5	104.2 ± 2.6; 100.1 ± 4.8
Freeze-thaw	94.8 ± 4.1; 101.2 ± 3.1	96.0 ± 7.4; 101.3 ± 2.3	93.6 ± 1.7; 98.2 ± 3.7	94.8 ± 3.7; 101.8 ± 3.6
30 days at −80 °C	96.5 ± 4.6; 95.3 ± 7.1	101.9 ± 2.8; 103.0 ± 5.8	90.8 ± 7.1; 96.0 ± 4.0	93.3 ± 5.0; 96.0 ± 4.6