Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 26;9(1):1696517. doi: 10.1080/20013078.2019.1696517

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 6. — PK analysis of the secretion/clearance balance of MP-sEVs based on intravenous infusion in a two-compartment model. The image above shows the schematic concept. MP-sEVs are secreted from various cells or organs. Under the assumption of this model, the MP-sEVs are secreted into plasma based on zero-order kinetics. MP-sEV clearance from circulation is assumed to follow first-order kinetics. k_el or k_elˊ: MP-sEV clearance rate constant (min⁻¹). C_sEV or C_sEVˊ: MP-sEV concentration in blood (μg/mL). V_c or V_cˊ: volume of distribution (mL). k₀: MP-sEV secretion rate constant (μg/min). The k₀ value was assumed to be constant before and after macrophage depletion treatment. The table below summarizes the PK parameters based on experimental data from Figures 3 and 4.