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Isolated rabbit scleral penetration fitting parameters of different models.
| Formulation | Models | Equations | R2 |
|---|---|---|---|
| Micelles | Zero-order | Q = 0.184t − 0.485 | 0.9842 |
| First-order | Q = 104.12(1 − e−0.00183t) | 0.9824 | |
| Higuchi | Q = 2.311×(t0.5)−6.462 | 0.9958 | |
| Nanosuspension | Zero-order | Q = 0.652t − 4.444 | 0.9189 |
| First-order | Q = 68.955(1 − e−0.0132t) | 0.9297 | |
| Higuchi | Q = 7.147×(t0.5)−18.032 | 0.9540 |
