Table 1. Pertussis vaccination programme used in Catalonia (Spain) since 1965.
| Primary doses | Booster doses | |||||
|---|---|---|---|---|---|---|
| Year | Vaccine type | Schedule | Pertussis components | Vaccine type | Schedule | Pertussis components |
| 1965 | DTPw | 2 doses between 3 months and 3 years | Inactivated whole cell | NA | No booster | NA |
| 1967 | DTPw | 3 doses between 3 months and 3 years | Inactivated whole cell | NA | No booster | NA |
| 1975 | DTPw | 3, 5, 7 months | Inactivated whole cell | NA | No booster | NA |
| 1996 | DTPw | 2–3, 4–5, 6–7 months | Inactivated whole cell | DTPw | 15–18 months | Inactivated whole cell |
| 1998–1999 | DTPw | 2, 4, 6 months | Inactivated whole cell | DTPa | 18 months 4–6 years | PT, FHA, PRN |
| 2000 | DTPw/DTPa | 2, 4, 6 months | Inactivated whole cell or PT, FHA, PRN | DTPa | 18 months 4–6 years | PT, FHA, PRN |
| 2002 | DTPa | 2, 4, 6 months | PT, FHA, PRN | DTPa | 18 months 4–6 years | PT, FHA, PRN |
| 2011 | DTPa | 2, 4, 6 months | PT, FHA, PRN | DTPa/dTpa | 18 months (DTPa), 4–6 years (dTpa) | PT, FHA, PRN or PT, FHA, PRN, FIM2, FIM3a |
| 2014 | DTPa | 2, 4, 6 months | PT, FHA, PRN | DTPa/dTpa | 18 months (DTPa), 6 years (dTpa) | PT, FHA, PRN or PT, FHA, PRN, FIM2, FIM3a |
| 2014b | NA | NA | NA | dTpa | between 27 through 36 weeks of pregnancy | PT, FHA, PRN or PT, FHA, PRN, FIM2, FIM3 |
Notes: NA: not applicable; DTPw: diphtheria-tetanus-whole cell pertussis vaccine; DTPa: diphtheria-tetanus-acellular pertussis vaccine; dTpa: diphtheria-tetanus-accellular pertussis vaccine with reduced antigenic load of diphtheria, tetanus and pertussis; PT: pertussis toxin; FHA: filamentous haemagglutinin; PRN: pertactin; FIM2: type 2 fimbriae; FIM3: type 3 fimbriae. These data have been collected from Campins M, et al ([1] and personal communication).
aThe composition containing pertussis fimbrial antigens is used in some cases for the fifth dose.
bIntroduction of maternal pertussis vaccination.