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The binding mode of PF-543 with the SphK1. (A) The overall structure of SphK1–PF-543 complex showing protein in cartoon model and ligand in stick. (B) Interaction of PF-543 to the SphK1 residues (stick). (C) 2D diagram of SphK1 interaction with the compound PF-543. The active site residues of SphK1 interacting with ligand PF-543 by one conventional H-bonds.
