Table 2.

possible factors influencing efficiency of particle size reduction.

API property	Reference
particle size/ crystallite size	(Liu et al., 2018)
polymorphism	(Sharma et al., 2011)
particle morphology	(Liu et al., 2016, 2018, 2018)
solid state	(Salazar et al., 2011, 2013; Liu et al., 2018)
Young’s modulus	(Cerdeira et al., 2011)