Table 4.
The chemical stability of different dosage forms during storage at 4 and 25 °C.
| Dosage forms | Temperature (°C) | Percentages of
lycopene remaining (%) |
|||||
|---|---|---|---|---|---|---|---|
| Baseline | 1 week | 2 weeks | 4 weeks | 6 weeks | 8 weeks | ||
| LOO | 4 | 100 | 92.25 ± 2.90 | 86.45 ± 3.81 | 82.83 ± 2.65 | 79.71 ± 2.36 | 75.76 ± 1.82 |
| 25 | 100 | 91.85 ± 2.70 | 85.17 ± 3.93 | 78.10 ± 1.79 | 74.62 ± 1.31 | 70.14 ± 3.25 | |
| Optimized LME | 4 | 100 | 96.03 ± 2.48 | 92.99 ± 2.82* | 90.31 ± 3.20** | 88.76 ± 1.96**& | 87.04 ± 2.43**& |
| 25 | 100 | 95.11 ± 2.81 | 91.66 ± 2.69# | 87.38 ± 2.01## | 84.58 ± 1.74## | 82.09 ± 2.60## | |
LOO: lycopene dissolved in olive oil; LME: lycopene-loaded microemulsion.
Each value is the mean ± SD of three separate determinations. Baseline represents day 0. Statistical significances were performed by two-way ANOVA (Bonferroni correction).
*p < .05, **p < .01 compared with LOO at 4 °C.
#p < .05, ##p < .01 compared with LOO at 25 °C.
&
p < .05 compared with optimized LME at 25 °C.