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The CDKs inhibition activity of Milciclib and two hit compounds
| Compounds | CDKs IC50 (nM) |
Cells IC50 (μM) |
||
|---|---|---|---|---|
| CDK2 | CDK4 | HCT116 | A549 | |
| Milciclib | 52.7 ± 3.1 | 240.1 ± 9.7 | 1.1 ± 0.3 | 3.7 ± 0.4 |
| Compound 1 | 67.0 ± 5.8 | 303.5 ± 11.3 | 7.2 ± 1.4 | 23.8 ± 3.2 |
| Compound 3 | 43.1 ± 1.4 | 490.3 ± 20.5 | 77.3 ± 2.0 | – |
