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Pharmaceutical properties of 15, 25 and C10a.
| Cpd. | MW | HB donors | HB acceptors | cLog P | Rotatable bonds | TPSA (Å2) |
GI absorption | P-gp substrate | Cytotoxicity |
|---|---|---|---|---|---|---|---|---|---|
| 15 | 466 | 2 | 7 | 4.23 | 8 | 110.13 | High | Yes | Low |
| 25 | 422 | 1 | 5 | 4.68 | 7 | 72.83 | High | Yes | Low |
| C10a | 588 | 1 | 5 | 7.32 | 5 | 80.67 | Low | No | High |
cLog P: consensus log of the octanol/water partition coefficient; GI absorption: gastrointestinal absorption; MW: molecular weight; TPSA: topological polar surface area.
