Table 3.
Pharmacokinetic profiles of compounds 17a, 17b in ICR mice.a
| Compounds | 17a | 17b |
|---|---|---|
| AUC 0∼24 (ng·h/mL) | 861.2 | 233.7 |
| Cmax (ng/mL) | 479.3 | 74.8 |
| T1/2 (h) | 1.2 | 5.2 |
| Bioavailability (%) | 19 | 0.7 |
a
All parameters were determined after oral administration (10 mg/kg, n = 3) and intravenous (iv) injection (3 mg/kg, n = 2) in ICR mice; both compounds were dissolved in a vehicle solution of DMSO/Tween80/saline (1:6:23) for iv., and 0.5% methylcellulose/0.5% Tween80 in distilled water for oral administration. Data represent mean values.