. 2019 Nov 22;35(1):227–234. doi: 10.1080/14756366.2019.1693555

Table 5.

In vitro microsomal stability and cytochrome P450 (CYP) inhibition assay of compound 17a.

	Microsomal stability, (%)^a				CYPs enzyme inhibition, IC₅₀ (μM)^b
No	Human	Dog	Rat	Mouse	CYP3A4	CYP1A2	CYP2C9	CYP2C19	CYP2D6
17a	94	82	87	82	16.2	10.6	2.9	>20	8.7

^{^a}

Remaining percent of metabolism by incubation of the parent molecule (5 μM) with liver microsomes of mouse, rat, dog, and human for 60 min (duplicate).

^{^b}

Data were analysed by a fluorescence detection method.