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. Author manuscript; available in PMC: 2020 Aug 5.
Published in final edited form as: Sci Signal. 2019 Nov 5;12(606):eaau2281. doi: 10.1126/scisignal.aau2281

Fig. 4. TFEB transcriptionally drives browning in iWAT.

Fig. 4.

Transcriptional characterization in fat pads from female mice fed a Western diet for 4 months. (A) Autophagy and lysosomal genes in iWAT (n = 9 control and 7 Adipo-TFEB mice). (B) Autophagy and lysosomal genes in BAT (n = 9 control and 7 Adipo-TFEB mice). (C) Adipose tissue browning genes in iWAT (n = 9 control and 7 Adipo-TFEB mice). (D) Adipose tissue browning genes in BAT (n = 9 control and 7 Adipo-TFEB mice). (E) Representative UCP-1 immunohistochemistry of iWAT (n = 5 control and 5 Adipo-TFEB mice). Scale bar, 100 μm. Data are presented as means ± SEM. Mann-Whitney U (for UCP-1 only) and Student’s two-tailed t test, *P < 0.05.