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. 2019 Aug 13;4(5):e776. doi: 10.1097/PR9.0000000000000776

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — An OPLS-DA (orthogonal partial least square discriminant analysis) model showing separation between plasma protein at time point 1 (morning) and time point 2 (evening). The longitudinal dimension (y-axis) shows the interclass discrimination, and the latitudinal dimension (x-axis) shows the intraclass discrimination between the groups. Score plot (A) shows the separation between T1 (Triangles) and T2 (diamonds). Loading plot (B) corresponding to significant proteins with a VIP value >1 important for evening (blue square, T2) and morning (green triangle, T1). The proteins are labelled according to their UniProt designation (see supplementary Table 1, available at http://links.lww.com/PR9/A48).